The Boomers showed the benefit of their hit-out on Tuesday, showcasing a more cohesive style of play at both ends of the court while they almost played a full side with the addition of Matthew Dellavedova and Chris Goulding substituting for David Andersen who was rested with very slight knee soreness.
Australia's switched-on play was evidenced in the first half of the third period when Joe Ingles threw a bullet pass to Aron Baynes under the rim for a three-point play before a touch pass from Dellavedova set up Patty Mills for a four-point play after being fouled beyond the arc.
Those back-to-back offensive plays gave the Boomers their biggest lead of the game at that point and Mills went on to score 29 points on 5-9 three-point shooting in a scintillating performance while Ingles played facilitator to perfection with eight points and 11 assists.
He helped Australia record 29 total assists on 31 field goals, a sure-fire recipe to success in Rio next month.
"It was a good improvement on Tuesday," said coach Lemanis.
"We're inching forward and getting better each day. I thought we made a significant improvement defensively and perhaps we were over anxious on Tuesday. Sometimes it's about playing smarter, not harder.
"I didn't fully appreciate how much it means for the guys to play in Melbourne and they were nervous believe it or not.
"It means so much to be playing in front of home fans and family and friends so I thought tonight we played a bit freer in terms of our mental state."
Brock Motum, who had 14 points and nine rebounds as a starter, also saw a vast improvement from Game 1 of the Farewell Series.
"I think as a team we've made steps. If we can peak at the right time before the first game in Rio, we'll be good."
Ingles brought the crowd into the game on the first play of the night as he sliced through the defence with ease for a slam dunk.
Brock Motum and Mills then backed up the high-intensity play with three-pointers as Australia continued to practice their full-court defence which coach Andrej Lemanis has stated will be their strategy in Rio.
Lorenzo Bonam helped cut into the lead early while Tra Holder also kept the Pac-12 All-Stars close but Australia finally gained some separation as Ingles helped Mills leak out on several fast breaks.
The hosts forced nine turnovers in the first half and had eight players hit the scoreboard, extending their lead to 12 at the main break before their third-quarter onslaught sealed the deal.
"I don't think the Boomers were very pleased from the first night and they played really hard," said Pac-12 All-Stars coach Mike Montgomery.
"You could see the difference in how hard they played. Their pace got us out of whack a little bit but I thought we didn't back off and we competed."
Every Boomer bar Damian Martin scored although the Wildcat did collect two rebounds and an assist while Aron Baynes was just as dominant under the rim as Tuesday with 19 points and eight rebounds.
The full box score is available here.
Meanwhile in the curtain-raiser, the Aussie Rollers put the NWBL All-Stars to the sword in a clinical performance.
Brad Ness (nine points, eight boards) hit the court for the Rollers after missing the first game and made an immediate impact, scoring the first basket of the game.
He was quickly followed by Tristan Knowles (ten points, five rebounds) and Shaun Norris (22 points, four assists) as the national team jumped out to an 18-6 lead at quarter-time.
Their speed up the floor simply proved too much for the All-Stars to handle and with Tom O'Neill-Thorne (five points, two steals) getting in on the act in the second period, their advantage jumped out to 22.
Out of the main break, Nick Taylor (ten points, six rebounds) caught fire for the All-Stars with three straight baskets.
However, they were unable to cut into the margin with the Rollers' bench just as efficient at their offensive end and when Norris nailed two three-pointers late in the term, the reigning World Champions had snuffed out any hope of a comeback.
Luke Pople (nine points, four rebounds) was able to put on a show in the final quarter, hitting a three-pointer of his own and setting up Jay Dohnt with a no-look pass as the All-Stars won their first term of the series to make the final scoreline 65-42.
Full stats for that clash can be found here.
The Rollers final team for Rio will be announced early next week while the Boomers now head to South America for a series of warm-up games before August.