A strong fight from Belgium in the first half of their clash saw the Opals leading by just eight points at the main break but Australia raced away in the second half to record a convincing 81-54 win.
Liz Cambage was devastating in the paint, recording 26 points and seven rebounds while guards Katie-Rae Ebzery (13 points) and Tess Madgen (ten points) also hit double-figures in scoring.
The following night against Cameroon, the Opals made sure their opposition were not given a sniff as they extended a 25 point half-time margin to win 82-28.
Coach Brendan Joyce was pleased with his side's second leg of the European tour, having swept their three opponents.
"The games in Italy were a great opportunity to work on our game from an offence and defensive perspective," Joyce said.
"It is always a positive experience to play against different styles of play [and] it was pleasing to finish the tournament with a strong performance against Cameroon."
The Jayco Opals will now finish their tour with three games in France against China, Canada and France from June 7-10.
Their preparation for August will then culminate with two more Australians camps in late June (Canberra) and early July (Gold Coast) where the final team will be announced.