Leading by ten points at the first break, Australia proved they were the dominant team with a 25-7 second term blitz before they ran out 90-48 winners.
Despite an interrupted start to the tour which saw half of the team's bags not make it across on the flight to Spain, head coach Brendan Joyce was pleased with the Opals' complete performance.
"We played our trademark consistent and strong defence over four quarters tonight, combined with good offensive execution," he said.
A double-double for Liz Cambage (23 points, ten rebounds) and significant contributions from Katie-Rae Ebzery (13 points) and Tess Madgen (10 points) who was coming off an ankle injury helped Australia secure the win.
In her first game with the side since another successful season in France, Laura Hodges also impressed with 10 points, three boards and three assists.
"[Our] solid game provides us with good preparation for what is expected to be a tough game against Spain tonight," Joyce said.
Following that game, the Opals will head to Italy for a three-game stretch against Italy on June 2, Belgium on June 3 and Cameroon on June 4 before the tour continues the following week in France.