Justin Eveson led the Rollers again with 21 points and a game high four steals. Shaun Norris had another double-double with 15 points and 11 assists.
Raul Ortega was the only Mexican to score in double figures with 10 points.
The Australians got away to a 26-10 lead at the first quarter and were never in any danger of succumbing to Mexico.
A 20-2 third quarter sealed the victory as the Rollers stepped up their defensive effort, forcing Mexico to take difficult shots; Mexico scored only two points in the entire quarter.
The Rollers next take on rival Canada at 4.00am Tuesday July 13 AEST.
Quarter by quarter:
1: AUS 26 MEX 10
H: AUS 50 MEX 25 (24-15)
3: AUS 70 MEX 27 (20-2)
F: AUS 81 MEX 43 (11-16)
AUSTRALIA 81 (J Eveson 21, T Knowles 17, S Norris 15) def
MEXICO 43 (R Ortega 10, E Perdomo 7, S Martinez 6)
At National Indoor Arena, Birmingham, England.